Alteration of central motor excitability in a patient with hemimasticatory spasm after treatment with botulinum toxin injections
Identifieur interne : 003598 ( Main/Exploration ); précédent : 003597; suivant : 003599Alteration of central motor excitability in a patient with hemimasticatory spasm after treatment with botulinum toxin injections
Auteurs : Pablo Mir [Royaume-Uni, Espagne] ; Francesca Gilio [Italie] ; Mark Edwards [Royaume-Uni] ; Maurizio Inghilleri [Italie] ; Kailash P. Bhatia [Royaume-Uni] ; John C. Rothwell [Royaume-Uni] ; Niall Quinn [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-01.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Blinking (drug effects), Blinking (physiology), Bontoxilysin, Botulinum Toxins, Type A (adverse effects), Botulinum Toxins, Type A (therapeutic use), Brain Stem (drug effects), Brain Stem (physiopathology), Chronic Disease, Electric Stimulation, Electromyography (drug effects), Excitability, Functional Laterality (drug effects), Functional Laterality (physiology), Human, Humans, Injections, Intramuscular, Male, Masseter Muscle (drug effects), Masseter Muscle (innervation), Middle Aged, Motor Neurons (drug effects), Motor Neurons (physiology), Nerve Net (drug effects), Nerve Net (physiopathology), Nervous system diseases, Neural Inhibition (drug effects), Neural Inhibition (physiology), Palpebral reflex, Reaction Time (drug effects), Reaction Time (physiology), Recurrence, Signal Processing, Computer-Assisted, Spasm, Spasm (drug therapy), Spinal Nerve Roots (drug effects), Spinal Nerve Roots (physiopathology), Treatment, Trigeminal Nerve (drug effects), Trigeminal Nerve (physiopathology), blink reflex, botulinum toxin, hemimasticatory spasm.
- MESH :
- chemical , adverse effects : Botulinum Toxins, Type A.
- drug effects : Blinking, Brain Stem, Electromyography, Functional Laterality, Masseter Muscle, Motor Neurons, Nerve Net, Neural Inhibition, Reaction Time, Spinal Nerve Roots, Trigeminal Nerve.
- drug therapy : Spasm.
- innervation : Masseter Muscle.
- physiology : Blinking, Functional Laterality, Motor Neurons, Neural Inhibition, Reaction Time.
- physiopathology : Brain Stem, Nerve Net, Spinal Nerve Roots, Trigeminal Nerve.
- chemical , therapeutic use : Botulinum Toxins, Type A.
- Chronic Disease, Electric Stimulation, Humans, Injections, Intramuscular, Male, Middle Aged, Recurrence, Signal Processing, Computer-Assisted.
Abstract
Hemimasticatory spasm (HMS) is a condition characterized by paroxysmal involuntary contraction of masticatory muscles. We performed an electrophysiological investigation of a single patient with HMS to identify any pathophysiological changes associated with the condition. We identified a delayed M wave and jaw jerk on the affected side and an absent masseteric silent period during spasm. Botulinum toxin injections successfully treated the clinical symptoms and resulted in a significant reduction in the excitability of the blink reflex recovery cycle. These data suggest that HMS may be due to ectopic activity in the motor portion of the trigeminal nerve that is capable of inducing changes in the excitability of central reflex pathways. These changes can be altered by successful treatment with botulinum toxin. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20653
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-01">2006-01</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="73">73</biblScope><biblScope unit="page" to="78">78</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B72FF9DF168A37F7908EE06CB8A7B7296CB4F6EB</idno><idno type="DOI">10.1002/mds.20653</idno><idno type="ArticleID">MDS20653</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blinking (drug effects)</term><term>Blinking (physiology)</term><term>Bontoxilysin</term><term>Botulinum Toxins, Type A (adverse effects)</term><term>Botulinum Toxins, Type A (therapeutic use)</term><term>Brain Stem (drug effects)</term><term>Brain Stem (physiopathology)</term><term>Chronic Disease</term><term>Electric Stimulation</term><term>Electromyography (drug effects)</term><term>Excitability</term><term>Functional Laterality (drug effects)</term><term>Functional Laterality (physiology)</term><term>Human</term><term>Humans</term><term>Injections, Intramuscular</term><term>Male</term><term>Masseter Muscle (drug effects)</term><term>Masseter Muscle (innervation)</term><term>Middle Aged</term><term>Motor Neurons (drug effects)</term><term>Motor Neurons (physiology)</term><term>Nerve Net (drug effects)</term><term>Nerve Net (physiopathology)</term><term>Nervous system diseases</term><term>Neural Inhibition (drug effects)</term><term>Neural Inhibition (physiology)</term><term>Palpebral reflex</term><term>Reaction Time (drug effects)</term><term>Reaction Time (physiology)</term><term>Recurrence</term><term>Signal Processing, Computer-Assisted</term><term>Spasm</term><term>Spasm (drug therapy)</term><term>Spinal Nerve Roots (drug effects)</term><term>Spinal Nerve Roots (physiopathology)</term><term>Treatment</term><term>Trigeminal Nerve (drug effects)</term><term>Trigeminal Nerve (physiopathology)</term><term>blink reflex</term><term>botulinum toxin</term><term>hemimasticatory spasm</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Botulinum Toxins, Type A</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blinking</term><term>Brain Stem</term><term>Electromyography</term><term>Functional Laterality</term><term>Masseter Muscle</term><term>Motor Neurons</term><term>Nerve Net</term><term>Neural Inhibition</term><term>Reaction Time</term><term>Spinal Nerve Roots</term><term>Trigeminal Nerve</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Spasm</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Masseter Muscle</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blinking</term><term>Functional Laterality</term><term>Motor Neurons</term><term>Neural Inhibition</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain Stem</term><term>Nerve Net</term><term>Spinal Nerve Roots</term><term>Trigeminal Nerve</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Botulinum Toxins, Type A</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Chronic Disease</term><term>Electric Stimulation</term><term>Humans</term><term>Injections, Intramuscular</term><term>Male</term><term>Middle Aged</term><term>Recurrence</term><term>Signal Processing, Computer-Assisted</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Bontoxilysin</term><term>Excitabilité</term><term>Homme</term><term>Réflexe palpébral</term><term>Spasme</term><term>Système nerveux pathologie</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hemimasticatory spasm (HMS) is a condition characterized by paroxysmal involuntary contraction of masticatory muscles. We performed an electrophysiological investigation of a single patient with HMS to identify any pathophysiological changes associated with the condition. We identified a delayed M wave and jaw jerk on the affected side and an absent masseteric silent period during spasm. Botulinum toxin injections successfully treated the clinical symptoms and resulted in a significant reduction in the excitability of the blink reflex recovery cycle. These data suggest that HMS may be due to ectopic activity in the motor portion of the trigeminal nerve that is capable of inducing changes in the excitability of central reflex pathways. These changes can be altered by successful treatment with botulinum toxin. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Espagne</li><li>Italie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mir, Pablo" sort="Mir, Pablo" uniqKey="Mir P" first="Pablo" last="Mir">Pablo Mir</name></region><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name><name sortKey="Edwards, Mark" sort="Edwards, Mark" uniqKey="Edwards M" first="Mark" last="Edwards">Mark Edwards</name><name sortKey="Quinn, Niall" sort="Quinn, Niall" uniqKey="Quinn N" first="Niall" last="Quinn">Niall Quinn</name><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name></country><country name="Espagne"><noRegion><name sortKey="Mir, Pablo" sort="Mir, Pablo" uniqKey="Mir P" first="Pablo" last="Mir">Pablo Mir</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Gilio, Francesca" sort="Gilio, Francesca" uniqKey="Gilio F" first="Francesca" last="Gilio">Francesca Gilio</name></noRegion><name sortKey="Inghilleri, Maurizio" sort="Inghilleri, Maurizio" uniqKey="Inghilleri M" first="Maurizio" last="Inghilleri">Maurizio Inghilleri</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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